Webpage for Patrick Slama @ CIS

Center for Imaging Science 

Institute for Computational Medicine

	Patrick Slama
	Masters in Physical Chemistry, Lyon, France
	Ph. D. in Molecular chemistry - Biochemistry, Marseilles, France
	Current: post-doc at CIS, JHU, Baltimore Identification of biomarkers for ischemia using shotgun proteomics Sequence-based analysis of histone-interacting proteins and domains Softwares
		Research fellow in Berlin, Germany Structural Bioinformatics Graph representation of protein structures, new methods for the detection of protein active sites and for the prediction of their three dimensional structure
	Research fellow at INSERM, Créteil, France Characterization of two new interactions for the C-terminal tail of the Dopamine Transporter (DAT)
		Research fellow in Washington, DC and Gif-sur-Yvette, France Regulation of the Serotonin Transporter
	Ph. D. thesis in Marseilles, France Catalytic mechanism of Dopamine β-Hydroxylase Supervision: Dr. Marius Réglier Study of the interaction of the copper-containing enzyme Dopamine β-Hydroxylase with its reduction co-factor Mechanistic analogies using a chemical functional model

	List of publications
	Bioinformatics
	Identification of family-determining residues in PHD fingers view P. Slama and D. Geman, Nucleic Acids Research 39(5), 1666-1679 Detection of protein active sites at high precision using local residue network properties P. Slama, I. Filippis and M. Lappe, BMC Bioinformatics 9(1),517
	Inorganic Biochemistry
	N-Hydroxyguanidines oxidation by a N₃S copper-complex mimicking the reactivity of Dopamine β-Hydroxylase view P. Slama, J.-L. Boucher and M. Réglier, Journal of Inorganic Biochemistry 103(3), 455-462 Aromatic N-hydroxyguanidines as new reduction cosubstrates for Dopamine β-hydroxylase view P. Slama, J.-L. Boucher and M. Réglier, Biochemical and Biophysical Research Communications 316, 1081-1087 Copper-containing monooxygenases: enzymatic and biomimetic studies of the O-atom transfer I. Blain, P. Slama, M. Giorgi, T. Tron and M. Réglier, Reviews in molecular technology 90, 95-112 (review)