PEDIATRIC AND DEVELOPMENT COLLABORATION
Content
TRD4 is involved in the following major collaborations in the pediatric brain and in the changing brain:
PEDIATRIC COLLABORATION
1. ADHD and Autism in the Pediatric Brain (Mostofsky)
White matter volume and motor skills. Top chart: In children with autism, a greater volume of white matter in the brain’s motor cortex predicts poorer motor skills (higher PANESS scores). Bottom chart: The opposite relationship is seen in typically developing (TD) children. Greater white matter volume predicts a lower PANESS score, a measure of better motor skills. (Charts courtesy of Dr. Stewart Mostofsky, Kennedy Krieger Institute).
2. Major Depressive Disorder (MDD) in the Pediatric Brain (Botteron)
Labelled Cortical Distance Maps (LCDMs) in the Ventral Medial Prefrontal Cortex in Depressed, High Risk and Control Twins. Graphs show average LCDM grey matter profiles (row 1), average normalized LCDM grey matter profiles (row 2) and CMD profiles (row 3) for the left and right VMPFC. For the left VMPFC, the High Risk (HR) population is stochastically larger than the MDD population. For the right VMPFC, the control population is stocastically larger thna both HR and MDD populations.
DEVELOPMENT COLLABORATION
3. The Changing Brain in Normal Aging and Alzheimer’s Disease (Albert)
Shape Changes in the Left Hippocampus over time.
4. The Developing Brain in Schizophrenia: The Conte Center for Neuroscience of Mental Disorders at Washington University School of Medicine in St. Louis (Csernansky and Barch)
Examples of cortical depth profile—comparison subjects. Examples of cortical gray matter thickness distribution (maps) over the cingulate
surface as generated via LCMDM, in comparison subjects. Rows (a–c) show maps from three individuals with large thickness values in the right AC.
Rows (d–f) show maps from three individuals with small thickness values in the right AC.
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